Scientists have discovered important genes that increase young Indians’ susceptibility to Parkinson’s disease.
In order to improve our understanding of the genetic foundation of Parkinson’s disease, the team, lead by Parkinson’s Research Alliance of India (PRAI) and MedGenome, a global genomics firm in South Asia, conducted a thorough investigation of common and unusual genetic alterations in the young Indian population.
According to the team of scientists in the research published in the esteemed journal Movement Disorders, this also opens the door for the first-ever genetic screening for the condition in high-risk individuals and affected families in India.
“Parkinson’s disease is not caused by a single gene. various genetic mutations and various gene causes may be responsible for it. Movement disorders specialist Dr. Prashanth L.K. of PRAI said IANS that understanding what patients with Indian patients will experience will have a greater impact on understanding and treatment of it.
When it comes to neurodegenerative disorders among persons sixty years of age and older, Parkinson’s disease ranks second in frequency.
The Global Burden of Disease Study (2018) reports that during the previous 20 years, the prevalence of Parkinson’s disease has doubled worldwide, with 10% of cases occurring in India. This corresponds to around 0.58 million individuals in the nation who are afflicted with the illness.
Through a network of ten specialised Movement Disorder Centres and Neurology clinics around India, the first study of its sort was carried out with the goal of include 1,000 patients.
Dr. Prashanth told IANS that while Parkinson’s mutations are very common in Indian patients, the team also discovered a significant risk of non-mutation.
Many of what we refer to as variants of uncertain importance were also discovered by us. These are all significant genes that were discovered here and have not been documented in any journal.
“We need to work on these genes further to see how these genes can be important for occurrence of parkinson disease in in in patients,” he stated.
The specialist added that several BSN gene mutations are present in Indian individuals. The BSN gene is typically not associated with Parkinson’s disease and largely affects a person’s gait and balance.
Dr. Prashanth added that as Parkinson’s disease is an aging-related condition, there is now just one treatment option available for preventing the illness.
Nonetheless, having a high quality of life is crucial. appropriate diet, time, and regular exercise.”