The environment that increases risk of asthma

London : Researchers have warned that children exposed to higher levels of fine particles in the air (known as PM2.5) are more likely to develop asthma and persistent wheezing than children who are not exposed.

According to the study, published in the journal BMJ, PM2.5 can come from various sources, including power plants, motor vehicles and domestic heating.

The particles (about 3 per cent or less of the diameter of a human hair) can penetrate deep into the lungs and some may even enter the circulatory system. “These findings support emerging evidence that exposure to air pollution might influence the development of asthma,” said the study authors from the Aarhus University in Denmark.

Short term peak exposure to air pollution has been associated with worsening of asthma, whereas the risks of long term exposure and the timing of exposure for the onset of asthma is less clear.

In addition, the role of air pollution combined with other risk factors, such as socioeconomic status, on asthma is unclear so researchers in Denmark set out to identify risk factors (air pollution and family-related) for the onset of asthma and persistent wheezing in children.

Their findings are based on more than three million Danish children born from 1997 to 2014 and followed for asthma onset and persistent wheezing from age one year to 15 years.

Of these, 122,842 children were identified as having asthma and persistent wheezing (at an average age of 1.9 years).

This information was then linked to detailed air pollutant measurements at the children’s home addresses, parental asthma, maternal smoking, parental education and income.

After taking account of other potentially influential factors, the researchers found higher levels of asthma and persistent wheezing in children of parents with asthma and in children of mothers who smoked during pregnancy.

In contrast, lower levels of asthma and persistent wheezing were found in children of parents with high educational attainment and high incomes.

Exposure to PM2.5 as well as larger particulate matter (PM10) NO2 and nitrate was associated with an increased risk of asthma and persistent wheezing. However, only the positive association of PM2.5 with asthma and persistent wheezing remained robust across the different models and after further (sensitivity) analyses.

The researchers point to some limitations, such as a lack of information on nutrition and physical activity, and factors related to the children’s indoor environment.